Gamma-Cyclodextrin, Sulfated (High Sulfate, 14-17)

Description

Gamma Cyclodextrin Sulfated High (DS 14–17)

Gamma-cyclodextrin, sulfated (high sulfate, degree of substitution 14–17), is a highly specialized cyclodextrin derivative engineered to deliver maximum anionic charge density and strong electrostatic interaction capabilities. Produced by extensively sulfating the hydroxyl groups of native gamma-cyclodextrin, this material exhibits a powerful polyanionic profile that enables high-affinity binding to positively charged biomolecules, proteins, and viral components.

At Michigan Diagnostics LLC, we manufacture and supply high-purity gamma cyclodextrin sulfated (DS 14–17) with tight control over substitution levels, ensuring consistent performance across advanced biochemical, pharmaceutical, and antiviral research applications. Each batch is rigorously tested and supplied with a Certificate of Analysis (COA), supporting reproducibility in both academic and industrial settings.

Structural and Chemical Characteristics

Gamma-cyclodextrin is composed of eight α-1,4-linked glucose units arranged in a toroidal structure, forming the largest internal cavity among the three native cyclodextrins. This cavity is capable of accommodating relatively large hydrophobic molecules, making it valuable in inclusion-based applications. However, when heavily sulfated to a degree of substitution between 14 and 17, the molecule undergoes a functional shift.

Rather than acting primarily as an inclusion complex host, high-sulfate gamma cyclodextrin becomes dominated by electrostatic interactions. The introduction of numerous sulfate groups results in a dense negative charge distributed across the molecular surface. This transformation enhances water solubility and dramatically increases the molecule’s affinity for cationic species.

The result is a material that combines structural versatility with strong charge-driven interaction capabilities, making it uniquely suited for advanced biochemical systems.

Applications in Antiviral and Heparin-Mimetic Research

Highly sulfated cyclodextrins are widely studied for their ability to mimic glycosaminoglycans such as heparin. These naturally occurring molecules play a key role in biological processes, including viral attachment and cell signaling. By replicating their negative charge density, high-sulfate gamma cyclodextrin can interfere with these processes in controlled experimental systems.

Applications include:

• Viral entry inhibition studies
• Binding to viral surface proteins
• Modeling of host-pathogen interactions
• Investigation of electrostatic mechanisms in infection pathways
• Development of antiviral materials and screening systems

Because of its large cavity size and strong charge profile, gamma cyclodextrin sulfated (high DS) is particularly useful when working with larger viral proteins or complex biological targets.

Protein Binding and Biochemical Applications

The strong polyanionic nature of this material makes it ideal for high-affinity protein interaction studies. It can bind to positively charged regions of proteins, enabling researchers to investigate structure-function relationships, binding kinetics, and inhibition mechanisms.

Common applications include:

• High-affinity protein binding studies
• Charge-based inhibition experiments
• Stabilization of cationic proteins in solution
• Investigation of protein folding and aggregation
• Biomolecular interaction analysis

Its consistent charge density allows for reproducible results in systems where electrostatic interactions are a primary driver.

Drug Delivery and Advanced Formulation Systems

While inclusion complex formation is less dominant at high levels of sulfation, electrostatic interactions open new possibilities in drug delivery and formulation science. This material is particularly useful for interacting with positively charged therapeutic compounds or delivery systems.

Applications include:

• Binding and stabilization of cationic drugs
• Nanoparticle and liposomal system stabilization
• Ionic-controlled release mechanisms
• Targeted delivery strategies based on charge interactions
• Formulation of biologics and complex therapeutics

The high solubility and strong interaction capabilities make it a valuable tool in advanced pharmaceutical development.

Diagnostic and Analytical Applications

In diagnostic and analytical systems, high-sulfate gamma cyclodextrin can be used to improve assay performance and enable controlled interactions within complex mixtures.

Applications include:

• Stabilization of reagents in charged environments
• Enhancement of assay reproducibility
• Charge-based separation and analytical methods
• Support for biochemical assay development

Why Choose Michigan Diagnostics

Choosing a reliable gamma cyclodextrin sulfated high supplier in the USA is critical for ensuring quality, consistency, and supply chain reliability.

Michigan Diagnostics offers:

• Tight control of DS range (14–17)
• High-purity material with full COA documentation
• US-based manufacturing and fast 2–3 day shipping
• Custom synthesis and bulk supply options
• Technical support for complex applications

Our experience in cyclodextrin chemistry and diagnostic reagent manufacturing ensures that you receive material that performs consistently across demanding applications.

Packaging and Availability

Gamma-cyclodextrin sulfated (high DS 14–17) is available in:

• Research quantities
• Pilot-scale batches
• Bulk commercial volumes

Custom packaging and documentation are available upon request.

Order Gamma Cyclodextrin Sulfated (High DS 14–17)

If you are looking to buy gamma cyclodextrin sulfated high (DS 14–17), Michigan Diagnostics provides a dependable, high-quality solution with fast delivery and expert technical support. Contact us today to request a quote or discuss your application requirements.

Specifications

For research use. Custom quantities and bulk orders available — contact us for pricing.