Gamma-Cyclodextrin, Phosphated (High, 14-17)

Description

Gamma Cyclodextrin Phosphated High (DS 14–17)

Gamma-cyclodextrin, phosphated (high degree of substitution 14–17), is a highly advanced cyclodextrin derivative engineered to deliver exceptional aqueous solubility, superior buffer compatibility, and reliable performance in complex biochemical and pharmaceutical systems. By extensively phosphorylating the hydroxyl groups of native gamma-cyclodextrin, this material achieves a highly hydrophilic profile while retaining the large internal cavity that defines gamma cyclodextrin.

At Michigan Diagnostics LLC, we manufacture high-purity gamma cyclodextrin phosphated (DS 14–17) with tight control over substitution levels to ensure consistent batch-to-batch performance. Each lot is produced under strict quality standards and supplied with a Certificate of Analysis (COA), making it suitable for both research and commercial applications.

Structural and Functional Characteristics

Gamma-cyclodextrin is composed of eight α-1,4-linked glucose units arranged in a toroidal structure, resulting in the largest cavity among the native cyclodextrins. This cavity, approximately 7.5–8.3 Å in diameter, allows for the encapsulation of relatively large hydrophobic molecules and complex compounds that may not fit within alpha or beta cyclodextrins.

When phosphorylated to a high degree of substitution (DS 14–17), the molecule becomes significantly more hydrophilic and exhibits enhanced interaction with aqueous and buffered environments. Unlike sulfated cyclodextrins, which emphasize strong electrostatic binding, phosphated cyclodextrins provide a more moderate anionic character. This allows for improved compatibility with sensitive biological systems, minimizing the risk of protein denaturation or disruption of enzymatic activity.

At high levels of phosphorylation, the material shifts toward performance dominated by solubility, dispersion, and system compatibility, rather than strong binding interactions. This makes it particularly valuable in applications where maintaining solution stability and homogeneity is critical.

Key Properties

• Degree of Substitution (DS): 14–17 phosphate groups per molecule
• Charge Profile: Mild to moderately anionic
• Water Solubility: Extremely high
• Cavity Size: ~7.5–8.3 Å
• Functional Mode: Aqueous compatibility dominant
• Buffer Compatibility: Excellent

These properties make high-phosphated gamma cyclodextrin one of the most effective cyclodextrin derivatives for use in water-based systems.

Pharmaceutical and Drug Delivery Applications

Gamma-cyclodextrin phosphated (high DS) is widely used in pharmaceutical research and formulation development where high solubility and stability are required. Its large cavity enables encapsulation of larger drug molecules, while its high hydrophilicity ensures efficient dispersion in aqueous systems.

Applications include:

• Solubilization of large or poorly water-soluble active pharmaceutical ingredients (APIs)
• Stabilization of biologics, peptides, and protein-based therapeutics
• Formulation of injectable and aqueous drug delivery systems
• Reduction of aggregation in protein formulations
• Controlled release and targeted delivery systems

The high degree of phosphorylation enhances compatibility with physiological conditions, making it suitable for advanced drug development workflows.

Biochemical and Enzyme Applications

High-phosphated gamma cyclodextrin is particularly valuable in biochemical systems due to its ability to maintain stable, homogeneous solutions without introducing excessive ionic interactions.

Applications include:

• Enzyme stabilization in buffered environments
• Protein-compatible formulation systems
• Reduction of nonspecific interactions
• Enhancement of reagent solubility
• Optimization of biochemical assay performance

Because it provides improved solubility without strong binding interference, it is ideal for systems requiring gentle and consistent interaction conditions.

Diagnostic and Analytical Applications

Gamma-cyclodextrin phosphated (high DS) is well suited for diagnostic and analytical systems where reagent stability, solubility, and reproducibility are essential.

Applications include:

• ELISA and immunoassay systems
• Chemiluminescent assay stabilization
• Analytical separation and chromatography systems
• Reagent stabilization in diagnostic workflows
• Support for high-sensitivity biochemical assays

Its excellent compatibility with aqueous buffers ensures reliable performance across a wide range of laboratory and clinical applications.

Performance Advantages in Complex Formulations

One of the primary advantages of gamma-cyclodextrin phosphated (high DS 14–17) is its ability to maintain stability and dispersion in complex formulations. The high level of phosphorylation significantly reduces the risk of precipitation, even in high-concentration or multi-component systems.

This makes it particularly useful in:

• High-load pharmaceutical formulations
• Biologic and protein-based systems
• Multi-component diagnostic reagents
• Long-term storage solutions requiring stability

Additionally, the consistent substitution profile ensures predictable behavior across batches, which is critical for scaling from research to production.

Why Choose Michigan Diagnostics

Choosing a reliable gamma cyclodextrin phosphated supplier in the USA is essential for ensuring consistent quality and supply.

Michigan Diagnostics offers:

• Tight DS control (14–17) for reproducible results
• High-purity material with full COA documentation
• US-based manufacturing with fast 2–3 day shipping
• Custom synthesis and bulk supply capabilities
• Technical support for formulation and research

Our experience in cyclodextrin chemistry ensures dependable performance across demanding applications.

Packaging and Availability

Gamma-cyclodextrin phosphated (high DS 14–17) is available in:

• Laboratory research quantities
• Pilot-scale batches
• Bulk commercial volumes

Custom packaging and documentation are available upon request.

Order Gamma Cyclodextrin Phosphated (High DS 14–17)

If you are looking to buy gamma cyclodextrin phosphated high (DS 14–17), Michigan Diagnostics provides a dependable, high-quality solution with fast delivery and expert technical support. Contact us today to request pricing or discuss your application needs.