Gamma-Cyclodextrin, Sulfated (Low Sulfate, 5-8)

Description

Gamma-Cyclodextrin, Sulfated (Low Sulfate, DS 5–8)

Gamma-cyclodextrin, sulfated (low sulfate, degree of substitution 5–8), is a specialized derivative of native gamma-cyclodextrin designed to combine the advantages of large cavity inclusion complex formation with controlled anionic charge. By introducing a moderate number of sulfate groups onto the hydroxyl positions of the gamma-cyclodextrin molecule, this product achieves enhanced water solubility and selective electrostatic interaction capabilities without overwhelming biological systems with excessive ionic strength.

At Michigan Diagnostics LLC, we manufacture and supply high-purity gamma cyclodextrin sulfated (DS 5–8) for advanced research, pharmaceutical development, and biochemical applications. Each batch is produced under strict quality control with consistent substitution ranges, ensuring reproducibility across experiments and scalable processes.

Structural and Functional Characteristics

Gamma-cyclodextrin consists of eight α-1,4-linked glucose units arranged in a toroidal structure, forming the largest internal cavity among native cyclodextrins. This cavity is capable of encapsulating larger hydrophobic molecules compared to alpha or beta cyclodextrins. When sulfation is introduced at a low to moderate degree (DS 5–8), the molecule retains its inclusion capabilities while gaining a controlled negative charge profile.

This balance is critical. Lower degrees of sulfation preserve flexibility and compatibility in biological environments, allowing researchers to take advantage of both hydrophobic encapsulation and electrostatic binding without significantly disrupting protein conformation or assay conditions.

Applications in Pharmaceutical Research

Gamma-cyclodextrin sulfated (low DS) is particularly valuable in drug development where both solubility enhancement and controlled molecular interaction are required. Many modern drug candidates are large, hydrophobic, or structurally complex, making gamma cyclodextrin the ideal backbone for inclusion.

Applications include:

• Enhancing solubility of poorly water-soluble APIs
• Stabilizing large or lipophilic drug molecules
• Supporting controlled and sustained drug release
• Reducing aggregation in biologic formulations
• Improving delivery of complex therapeutic compounds

The moderate sulfate content also allows interaction with cationic drug molecules without excessive ionic binding that could limit release or bioavailability.

Biochemical and Protein Interaction Studies

In biochemical research, sulfated cyclodextrins are widely used for studying protein interactions due to their ability to mimic negatively charged biological molecules. The low sulfate version is particularly useful when gentle interaction is required.

Typical uses include:

• Protein binding and affinity studies
• Enzyme stabilization in solution
• Investigation of charge-dependent interactions
• Analytical method development
• Biomolecular structure-function research

Because the charge density is controlled, this product is well suited for systems where maintaining protein integrity is essential.

Diagnostic and Assay Applications

Low-sulfate gamma cyclodextrin is compatible with sensitive diagnostic platforms, including enzyme-based and chemiluminescent assays. It can enhance reagent stability and improve signal consistency without introducing excessive background interference.

Applications include:

• ELISA and immunoassay systems
• Chemiluminescent substrate stabilization
• Reagent preservation and shelf-life extension
• Signal reproducibility improvement

Why Choose Michigan Diagnostics

• Consistent DS range (5–8) across batches
• High-purity material with COA documentation
• Manufactured in the USA
• Fast 2–3 day shipping
• Custom synthesis and bulk supply available
• Technical support for formulation and research applications

Packaging and Availability

Available in multiple formats:

• Laboratory research quantities
• Pilot-scale batches
• Bulk commercial supply

Custom packaging and specifications are available upon request.

Order Gamma Cyclodextrin Sulfated (Low DS 5–8)

If you are looking to buy gamma cyclodextrin sulfated low (DS 5–8), Michigan Diagnostics provides a reliable, high-quality source with fast delivery and expert support for research and formulation needs.

Specifications

For research use. Custom quantities and bulk orders available — contact us for pricing.