Gamma-Cyclodextrin, Phosphated (Low, 5-8)

Description

Gamma Cyclodextrin Phosphated Low (DS 5–8)

Gamma-cyclodextrin, phosphated (low degree of substitution 5–8), is a modified cyclodextrin derivative engineered to enhance aqueous solubility, buffer compatibility, and performance in biological systems while retaining the large cavity structure characteristic of native gamma-cyclodextrin. By introducing phosphate groups onto the hydroxyl positions of the cyclodextrin molecule, this material achieves improved hydrophilicity and functional versatility, making it highly suitable for pharmaceutical, biochemical, and diagnostic applications.

At Michigan Diagnostics LLC, we manufacture high-purity gamma cyclodextrin phosphated (DS 5–8) with tight control over substitution levels to ensure consistent quality and reproducibility. Each batch is tested and supplied with a Certificate of Analysis (COA), supporting reliable use in both research and industrial environments.

Structural and Functional Characteristics

Gamma-cyclodextrin is composed of eight α-1,4-linked glucose units arranged in a toroidal structure, creating the largest internal cavity among the three native cyclodextrins. This cavity, approximately 7.5–8.3 Å in diameter, allows for encapsulation of relatively large hydrophobic molecules that cannot be accommodated by alpha or beta cyclodextrins.

When modified through phosphorylation at a low degree of substitution (DS 5–8), the molecule gains increased water solubility and improved compatibility with aqueous and buffered environments. Unlike sulfated cyclodextrins, which introduce strong electrostatic interactions, phosphated cyclodextrins provide a milder anionic character. This makes them particularly useful in systems where excessive ionic strength or strong binding interactions could interfere with biological activity or assay performance.

The result is a material that retains its inclusion complex capabilities while offering enhanced functionality in water-based systems.

Key Properties

• Degree of Substitution (DS): 5–8 phosphate groups per molecule
• Charge Profile: Mildly anionic
• Cavity Size: ~7.5–8.3 Å
• Water Solubility: Excellent
• Functional Mode: Inclusion complex formation + enhanced aqueous compatibility
• Buffer Compatibility: High

These properties make low-phosphated gamma cyclodextrin an ideal choice for applications requiring both solubility enhancement and system compatibility.

Pharmaceutical and Drug Delivery Applications

Gamma-cyclodextrin phosphated (low DS) is widely used in pharmaceutical research and formulation development, particularly for improving the solubility and stability of large or poorly water-soluble drug molecules.

Applications include:

• Solubilization of large hydrophobic active pharmaceutical ingredients (APIs)
• Stabilization of sensitive or labile drug compounds
• Improvement of formulation in aqueous and buffered systems
• Controlled release and delivery systems
• Reduction of aggregation in biologic and peptide formulations

The presence of phosphate groups enhances compatibility with physiological environments, making this material particularly useful in formulations intended for biological systems.

Biochemical and Enzyme Applications

One of the key advantages of gamma cyclodextrin phosphated (low DS) is its compatibility with enzyme systems and sensitive biochemical environments. The mild charge profile allows interaction without disrupting protein structure or function.

Applications include:

• Enzyme stabilization in aqueous buffers
• Protein-compatible formulation systems
• Reduction of nonspecific binding
• Improvement of reagent solubility
• Optimization of biochemical assay performance

Because it avoids the strong electrostatic effects seen with sulfated derivatives, this material is well suited for systems requiring subtle and controlled interactions.

Diagnostic and Analytical Applications

Gamma-cyclodextrin phosphated is also highly effective in diagnostic and analytical systems where reagent stability and reproducibility are critical.

Applications include:

• ELISA and immunoassay systems
• Chemiluminescent assay support
• Stabilization of diagnostic reagents
• Enhancement of signal reproducibility
• Analytical separation and chromatography systems

Its high solubility and compatibility with buffer systems make it particularly valuable in laboratory and clinical diagnostics.

Performance Advantages in Aqueous Systems

Gamma-cyclodextrin phosphated (low DS 5–8) offers a unique advantage in aqueous and buffered environments where traditional cyclodextrins may have limited solubility or compatibility. The introduction of phosphate groups improves dispersion and reduces the risk of precipitation, especially in complex formulations.

Additionally, the moderate level of substitution ensures that the molecule maintains flexibility and avoids excessive ionic interactions. This allows researchers to achieve consistent results in systems where stability, clarity, and reproducibility are essential.

Why Choose Michigan Diagnostics

Selecting a reliable gamma cyclodextrin phosphated supplier in the USA is critical for ensuring quality and consistency.

Michigan Diagnostics provides:

• Controlled DS range (5–8) for reproducible performance
• High-purity material with full COA documentation
• US-based manufacturing and fast 2–3 day shipping
• Custom synthesis and bulk supply options
• Technical support for formulation and research applications

Our expertise in cyclodextrin chemistry ensures consistent results across batches and applications.

Packaging and Availability

Gamma-cyclodextrin phosphated (low DS 5–8) is available in:

• Research quantities
• Pilot-scale batches
• Bulk commercial volumes

Custom packaging and documentation are available upon request.

Order Gamma Cyclodextrin Phosphated (Low DS 5–8)

If you are looking to buy gamma cyclodextrin phosphated low (DS 5–8), Michigan Diagnostics offers a dependable, high-quality solution with fast delivery and expert support. Contact us today to request a quote or discuss your application needs.