Beta-Cyclodextrin, Sulfated (Low Sulfate, 4-7)

Description

Beta Cyclodextrin Sulfated Low (DS 4–7)

Beta-cyclodextrin, sulfated (low sulfate, degree of substitution 4–7), is a highly versatile cyclodextrin derivative that combines efficient hydrophobic inclusion complex formation with a controlled level of anionic charge. Derived from native beta-cyclodextrin, this material is widely used across pharmaceutical, biochemical, and analytical research due to its optimal cavity size and balanced interaction profile.

At Michigan Diagnostics LLC, we manufacture high-purity beta cyclodextrin sulfated (DS 4–7) with strict control over substitution levels, ensuring consistent performance across experimental systems and scalable applications.

Structural and Functional Characteristics

Beta-cyclodextrin consists of seven α-1,4-linked glucose units arranged in a toroidal structure, creating a hydrophobic internal cavity approximately 6.0–6.5 Å in diameter. This cavity size is ideal for encapsulating a wide range of small to medium-sized hydrophobic molecules, making beta-cyclodextrin the most commonly utilized cyclodextrin in research and formulation science.

When sulfated at a low degree (DS 4–7), the molecule gains a moderate negative charge while retaining its ability to form inclusion complexes. This dual functionality allows it to interact with both hydrophobic and positively charged species, providing flexibility in a variety of applications.

Key Properties

• Degree of Substitution (DS): 4–7
• Charge Profile: Moderately anionic
• Cavity Size: ~6.0–6.5 Å
• Water Solubility: High
• Functional Mode: Inclusion complex + electrostatic interaction

This balanced profile makes low-sulfate beta cyclodextrin particularly useful in systems requiring both solubility enhancement and controlled molecular interaction.

Pharmaceutical and Drug Delivery Applications

Low-sulfate beta cyclodextrin is widely used in drug formulation due to its ability to improve solubility and stability of active pharmaceutical ingredients. Its cavity size is well suited for many commonly used drug molecules, making it a practical and effective excipient.

Applications include:

• Enhancing solubility of poorly water-soluble drugs
• Stabilizing sensitive or labile compounds
• Reducing drug aggregation in solution
• Supporting controlled and sustained release systems
• Improving bioavailability of lipophilic APIs

The moderate sulfate content allows interaction with cationic drugs without excessive ionic binding, ensuring proper release and bioavailability.

Protein Binding and Biochemical Research

Sulfated beta cyclodextrins are frequently used in protein interaction studies due to their ability to mimic negatively charged biological molecules. The low sulfate variant provides a gentler interaction profile, making it ideal for systems where protein integrity must be preserved.

Applications include:

• Protein binding and affinity studies
• Enzyme stabilization
• Investigation of electrostatic interactions
• Biomolecular structure-function analysis
• Analytical method development

Diagnostic and Analytical Applications

Low-sulfate beta cyclodextrin is compatible with a wide range of diagnostic and analytical systems.

Applications include:

• ELISA and immunoassay support
• Chemiluminescent assay stabilization
• Improvement of reagent stability
• Signal reproducibility enhancement
• Analytical separation techniques

Why Choose Michigan Diagnostics

• Tight DS control (4–7)
• High purity with COA documentation
• Manufactured in the USA
• Fast 2–3 day shipping
• Custom synthesis capabilities
• Technical support for applications

Packaging and Availability

Available in:

• Research quantities
• Pilot-scale batches
• Bulk production volumes

Order Beta Cyclodextrin Sulfated (Low DS 4–7)

If you are looking to buy beta cyclodextrin sulfated low (DS 4–7), Michigan Diagnostics offers a reliable, high-quality source with fast delivery and expert support.

Specifications

For research use. Custom quantities and bulk orders available — contact us for pricing.