Beta-Cyclodextrin, Sulfated (High Sulfate, 12-15)

Description

Beta Cyclodextrin Sulfated High (DS 12–15)

Beta-cyclodextrin, sulfated (high sulfate, degree of substitution 12–15), is a highly anionic cyclodextrin derivative engineered to provide strong electrostatic interaction capabilities for advanced biochemical, pharmaceutical, and antiviral research applications. By extensively sulfating the hydroxyl groups of native beta-cyclodextrin, this material achieves a dense negative charge profile that enables high-affinity binding to positively charged biomolecules, proteins, and molecular targets.

At Michigan Diagnostics LLC, we manufacture and supply high-purity beta cyclodextrin sulfated (DS 12–15) with tight control over substitution levels. Each batch is produced under strict quality standards and supplied with a Certificate of Analysis (COA), ensuring consistent performance across both research and industrial applications.

Structural and Chemical Characteristics

Beta-cyclodextrin consists of seven α-1,4-linked glucose units arranged in a truncated cone (toroidal) structure. This configuration creates a hydrophobic internal cavity approximately 6.0–6.5 Å in diameter, making it highly effective for encapsulating a wide range of small to medium-sized hydrophobic molecules.

When heavily sulfated to a degree of substitution between 12 and 15, the molecule undergoes a functional transformation. While native beta-cyclodextrin is primarily used for inclusion complex formation, the high sulfate derivative becomes dominated by electrostatic interactions. The introduction of multiple sulfate groups creates a strong polyanionic surface, significantly increasing affinity for positively charged species.

This shift in functionality makes high-sulfate beta cyclodextrin particularly valuable in applications where charge-based interactions are critical.

Key Properties

• Degree of Substitution (DS): 12–15 sulfate groups per molecule
• Charge Profile: Strongly anionic (polyanionic)
• Water Solubility: Very high
• Cavity Size: ~6.0–6.5 Å
• Functional Behavior: Electrostatic interaction dominant
• Binding Capability: High affinity for cationic molecules

The high degree of sulfation ensures strong and reproducible interactions in systems where charge density plays a central role.

Applications in Antiviral and Heparin-Mimetic Research

Highly sulfated cyclodextrins are widely studied for their ability to mimic glycosaminoglycans such as heparin, which play a key role in biological processes including viral attachment and cell signaling. By replicating this negative charge density, beta-cyclodextrin sulfated (high DS) can interact with viral proteins and cellular receptors, making it a valuable tool in antiviral research.

Applications include:

• Viral inhibition and binding studies
• Interaction with viral surface proteins
• Host-pathogen interaction modeling
• Screening of antiviral compounds
• Investigation of electrostatic mechanisms in infection pathways

Because beta-cyclodextrin is the most well-characterized cyclodextrin backbone, it is often the preferred choice for these types of studies.

Protein Binding and Biochemical Applications

The strong polyanionic nature of this material makes it highly effective for protein interaction studies. It can bind to positively charged regions of proteins, enabling detailed investigation of molecular interactions.

Common uses include:

• High-affinity protein binding studies
• Charge-based inhibition experiments
• Stabilization of cationic proteins
• Investigation of protein folding and aggregation
• Biomolecular interaction and kinetics studies

Its consistent charge density allows for reproducible experimental conditions, which is critical in biochemical research.

Drug Delivery and Advanced Formulation Systems

In pharmaceutical research, beta-cyclodextrin sulfated (high DS) is used in systems where electrostatic interactions are leveraged for drug delivery and formulation design.

Applications include:

• Binding and stabilization of cationic drug molecules
• Nanoparticle and liposomal formulation stabilization
• Controlled release systems based on ionic interactions
• Targeted delivery strategies using charge-based mechanisms
• Formulation of biologics and complex therapeutics

Although inclusion complex formation is less dominant at high sulfation levels, the molecule’s strong interaction capabilities provide alternative mechanisms for improving drug performance.

Diagnostic and Analytical Applications

High-sulfate beta cyclodextrin is also useful in diagnostic and analytical systems where charge-based interactions are important.

Applications include:

• Stabilization of assay reagents
• Enhancement of assay reproducibility
• Charge-based separation techniques
• Support for biochemical and analytical assay development

Why Choose Michigan Diagnostics

Selecting a reliable beta cyclodextrin sulfated high supplier in the USA is essential for ensuring product quality and consistency.

Michigan Diagnostics offers:

• Tight DS control (12–15) for reproducible performance
• High-purity material with full COA documentation
• US-based manufacturing and fast 2–3 day shipping
• Custom synthesis and bulk supply options
• Technical support for complex applications

Our expertise in cyclodextrin chemistry ensures consistent product quality across batches.

Packaging and Availability

Beta-cyclodextrin sulfated (high DS 12–15) is available in:

• Research quantities
• Pilot-scale batches
• Bulk commercial volumes

Custom packaging and documentation are available upon request.

Order Beta Cyclodextrin Sulfated (High DS 12–15)

If you are looking to buy beta cyclodextrin sulfated high (DS 12–15), Michigan Diagnostics provides a dependable, high-quality solution with fast delivery and expert technical support. Contact us today to request a quote or discuss your application requirements.

Specifications

For research use. Custom quantities and bulk orders available — contact us for pricing.