Description
Beta Cyclodextrin Phosphated Low (DS 4–7)
Beta-cyclodextrin, phosphated (low degree of substitution 4–7), is a versatile cyclodextrin derivative engineered to enhance aqueous solubility and compatibility while preserving the widely utilized inclusion complex properties of native beta-cyclodextrin. By introducing a controlled number of phosphate groups onto the cyclodextrin structure, this material offers improved dispersion and stability in aqueous and buffered systems without significantly altering its interaction profile.
At Michigan Diagnostics LLC, we manufacture high-purity beta cyclodextrin phosphated (DS 4–7) with strict control over substitution levels. Each batch is tested to ensure consistent performance across pharmaceutical, biochemical, and analytical applications.
Structural and Functional Characteristics
Beta-cyclodextrin consists of seven α-1,4-linked glucose units arranged in a toroidal structure, forming a hydrophobic cavity approximately 6.0–6.5 Å in diameter. This cavity size makes it ideal for encapsulating a wide range of small to medium-sized hydrophobic molecules, making beta-cyclodextrin the most commonly used cyclodextrin in research and formulation science.
Low-level phosphorylation (DS 4–7) enhances water solubility and compatibility with aqueous systems while maintaining the molecule’s ability to form inclusion complexes. Compared to highly charged derivatives, this version provides a more neutral interaction profile, making it suitable for sensitive biological environments.
Key Properties
- Degree of Substitution (DS): 4–7 phosphate groups
- Charge Profile: Mildly anionic
- Cavity Size: ~6.0–6.5 Å
- Water Solubility: High
- Functional Mode: Inclusion + aqueous compatibility
Pharmaceutical and Drug Delivery Applications
Beta-cyclodextrin phosphated (low DS) is widely used in drug formulation for improving solubility and stability of active pharmaceutical ingredients (APIs).
Applications include:
- Solubilization of poorly water-soluble drugs
- Stabilization of sensitive compounds
- Enhancement of aqueous drug formulations
- Controlled drug release systems
- Improved bioavailability of lipophilic molecules
The moderate level of phosphorylation ensures compatibility with physiological conditions without introducing excessive ionic interactions.
Biochemical and Enzyme Applications
This material is well suited for enzyme systems and protein-based applications due to its mild charge profile.
Applications include:
- Enzyme stabilization in buffered systems
- Reduction of nonspecific interactions
- Improved reagent solubility
- Protein-compatible formulation development
- Biochemical assay optimization
Diagnostic and Analytical Applications
Beta-cyclodextrin phosphated (low DS) is commonly used in diagnostic systems requiring stable and reproducible reagents.
Applications include:
- ELISA and immunoassays
- Chemiluminescent assays
- Analytical separations
- Reagent stabilization
- Laboratory assay development
Performance Advantages
Low phosphorylation improves dispersion and reduces precipitation in aqueous systems while preserving inclusion functionality. This makes it ideal for formulations requiring both solubility and structural compatibility.
Why Choose Michigan Diagnostics
- Controlled DS range (4–7)
- High purity with COA
- Fast US shipping (2–3 days)
- Custom synthesis available
- Technical support
Order Beta Cyclodextrin Phosphated (Low DS 4–7)
Michigan Diagnostics provides a reliable source of beta cyclodextrin phosphated low (DS 4–7) for research and formulation applications.
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