Description
Alpha Cyclodextrin Sulfated Low (DS 3–6)
Alpha-cyclodextrin, sulfated (low sulfate, degree of substitution 3–6), is a specialized cyclodextrin derivative designed to provide a combination of small-cavity inclusion capability and controlled anionic charge. Derived from native alpha-cyclodextrin, this material is particularly well suited for applications involving small molecules, enzyme systems, and biochemical environments where precise interaction control is required.
At Michigan Diagnostics LLC, we manufacture high-purity alpha cyclodextrin sulfated (DS 3–6) with strict control over substitution levels. Each batch is produced to ensure reproducibility, consistency, and performance across research and industrial applications.
Structural and Functional Characteristics
Alpha-cyclodextrin consists of six α-1,4-linked glucose units arranged in a toroidal structure. This results in the smallest internal cavity among the native cyclodextrins, with a diameter of approximately 4.7–5.3 Å. This smaller cavity size makes alpha-cyclodextrin particularly effective for interacting with small hydrophobic molecules and simple organic compounds.
When modified with sulfate groups at a low degree of substitution (DS 3–6), the molecule gains moderate anionic character while maintaining its structural integrity and inclusion properties. This enables dual functionality: hydrophobic encapsulation combined with controlled electrostatic interaction.
The relatively low sulfate content ensures that the molecule remains compatible with sensitive biochemical systems, minimizing disruption to proteins and enzymatic activity.
Applications in Pharmaceutical and Chemical Systems
Alpha-cyclodextrin sulfated (low DS) is used in systems where small molecules require stabilization or solubility enhancement. Its smaller cavity allows selective encapsulation of compounds that may not fit efficiently into beta or gamma cyclodextrins.
Applications include:
- Solubilization of small hydrophobic molecules
- Stabilization of volatile or sensitive compounds
- Controlled release systems for small-molecule drugs
- Reduction of compound degradation
- Support for formulation development
Biochemical and Enzyme Applications
Due to its controlled charge and small cavity, this material is particularly useful in enzyme systems and biochemical research.
Applications include:
- Enzyme stabilization in aqueous systems
- Controlled protein interaction studies
- Investigation of small molecule–protein interactions
- Biochemical assay development
- Analytical method optimization
The moderate charge density ensures interaction without significant denaturation or interference.
Diagnostic and Analytical Applications
Low-sulfate alpha cyclodextrin is compatible with sensitive diagnostic systems.
Applications include:
- ELISA and enzyme-based assays
- Stabilization of assay reagents
- Enhancement of signal reproducibility
- Analytical separation techniques
Performance Advantages in Controlled Systems
Alpha-cyclodextrin sulfated (low DS 3–6) offers a unique advantage in systems where precise control over molecular interactions is required. Because of its smaller cavity size and moderate charge density, it allows researchers to fine-tune interactions without introducing excessive ionic strength that could interfere with sensitive biological processes. This makes it particularly useful in applications involving delicate enzyme systems, receptor binding studies, and small molecule screening workflows.
Additionally, the lower degree of sulfation reduces the risk of nonspecific binding, which can be a concern with highly sulfated derivatives. This enables more accurate interpretation of experimental results, especially in kinetic and binding studies. As a result, this material is often selected for early-stage research and method development where control, reproducibility, and clarity of interaction are critical.
Why Choose Michigan Diagnostics
- Tight DS control (3–6)
- High purity with COA documentation
- US-based manufacturing
- Fast 2–3 day shipping
- Custom synthesis capabilities
- Technical support
Packaging and Availability
Available in:
- Research quantities
- Pilot-scale batches
- Bulk volumes
Order Alpha Cyclodextrin Sulfated (Low DS 3–6)
If you are looking to buy alpha cyclodextrin sulfated low (DS 3–6), Michigan Diagnostics provides consistent, high-quality material with fast delivery and expert support.
Specifications
| Property | Details |
|---|---|
| Form | White to off-white powder |
| Degree of Substitution | 3–6 sulfate groups |
| Cavity Size | Small (alpha, ~4.7–5.3 Å internal diameter) |
| Solubility | Soluble in water |
| Storage | Store at room temperature, away from moisture |
| Purity | ≥ 95% |
For research use. Custom quantities and bulk orders available — contact us for pricing.
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