Description
Alpha Cyclodextrin Phosphated High (DS 8–11)
Alpha-cyclodextrin, phosphated (high degree of substitution 8–11), is a highly functional cyclodextrin derivative engineered to provide maximum aqueous solubility, enhanced buffer compatibility, and improved performance in biochemical and pharmaceutical systems involving small molecules. By increasing the level of phosphorylation on the hydroxyl groups of native alpha-cyclodextrin, this material achieves a highly hydrophilic profile while retaining the unique small-cavity structure that defines alpha-cyclodextrin.
At Michigan Diagnostics LLC, we manufacture high-purity alpha cyclodextrin phosphated (DS 8–11) with tight control over substitution levels to ensure consistent performance across research and industrial applications. Each batch is produced under strict quality standards and supplied with a Certificate of Analysis (COA), ensuring reliability and reproducibility.
Structural and Functional Characteristics
Alpha-cyclodextrin consists of six α-1,4-linked glucose units arranged in a toroidal structure, forming the smallest internal cavity among cyclodextrins. This cavity, approximately 4.7–5.3 Å in diameter, is particularly well suited for encapsulating small hydrophobic molecules, simple organic compounds, and specific functional groups.
When highly phosphorylated (DS 8–11), the molecule becomes significantly more hydrophilic and exhibits excellent solubility in aqueous and buffered systems. The addition of phosphate groups increases compatibility with water-based environments while maintaining a relatively mild anionic charge profile compared to sulfated derivatives.
At higher levels of phosphorylation, the material shifts toward performance dominated by solubility, dispersion, and system stability, making it particularly useful in complex formulations and biochemical systems where maintaining homogeneity is critical.
Key Properties
- Degree of Substitution (DS): 8–11 phosphate groups per molecule
- Charge Profile: Mild to moderately anionic
- Water Solubility: Extremely high
- Cavity Size: ~4.7–5.3 Å
- Functional Mode: Aqueous compatibility dominant
- Buffer Compatibility: Excellent
These properties make high-phosphated alpha cyclodextrin ideal for applications requiring maximum solubility and precise control in small-molecule systems.
Pharmaceutical and Drug Delivery Applications
Alpha-cyclodextrin phosphated (high DS) is widely used in pharmaceutical research and formulation development where small molecules require efficient solubilization and stability in aqueous systems.
Applications include:
- Solubilization of small hydrophobic active pharmaceutical ingredients (APIs)
- Stabilization of labile or volatile compounds
- Formulation of aqueous drug delivery systems
- Controlled release of small-molecule therapeutics
- Reduction of degradation and precipitation in formulations
Because of its high solubility and compatibility, this material is particularly useful in early-stage formulation and in systems where traditional cyclodextrins may have limited aqueous performance.
Biochemical and Enzyme Applications
High-phosphated alpha cyclodextrin is especially valuable in biochemical systems due to its ability to maintain stable, homogeneous solutions without introducing strong electrostatic interactions.
Applications include:
- Enzyme stabilization in buffered environments
- Protein-compatible formulation systems
- Reduction of nonspecific interactions
- Enhancement of reagent solubility
- Optimization of biochemical assays and enzyme kinetics studies
Its moderate charge profile ensures that it interacts gently with proteins and enzymes, preserving their native structure and activity.
Diagnostic and Analytical Applications
Alpha-cyclodextrin phosphated (high DS) is well suited for use in diagnostic and analytical systems requiring high solubility and stability.
Applications include:
- ELISA and enzyme-based assays
- Chemiluminescent assay systems
- Analytical separation and chromatography
- Stabilization of diagnostic reagents
- High-sensitivity laboratory assays
Its compatibility with aqueous buffers ensures consistent performance across a wide range of laboratory conditions.
Performance Advantages in Complex Systems
One of the primary advantages of alpha-cyclodextrin phosphated (high DS 8–11) is its ability to maintain solubility and stability in complex and high-concentration formulations. The increased level of phosphorylation significantly reduces the risk of precipitation, even in multi-component systems.
This makes it particularly useful in:
- High-load pharmaceutical formulations
- Multi-component biochemical assays
- Long-term storage systems requiring stability
- Analytical workflows requiring consistent reagent performance
Additionally, the controlled substitution range ensures predictable behavior across batches, which is essential for scaling applications from research to production.
Why Choose Michigan Diagnostics
Selecting a reliable alpha cyclodextrin phosphated supplier in the USA is critical for ensuring consistent quality and performance.
Michigan Diagnostics offers:
- Tight DS control (8–11) for reproducibility
- High-purity material with full COA documentation
- US-based manufacturing with fast 2–3 day shipping
- Custom synthesis and bulk supply options
- Technical support for formulation and research
Packaging and Availability
Alpha-cyclodextrin phosphated (high DS 8–11) is available in:
- Laboratory research quantities
- Pilot-scale batches
- Bulk commercial volumes
Custom packaging and documentation are available upon request.
Order Alpha Cyclodextrin Phosphated (High DS 8–11)
If you are looking to buy alpha cyclodextrin phosphated high (DS 8–11), Michigan Diagnostics provides a dependable, high-quality solution with fast delivery and expert technical support. Contact us today to request pricing or discuss your application needs.
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