Description
Alpha Cyclodextrin Sulfated High (DS 8–11)
Alpha-cyclodextrin, sulfated (high sulfate, degree of substitution 8–11), is a highly functional cyclodextrin derivative designed to provide strong electrostatic interaction in systems involving small molecules and proteins. By increasing the level of sulfation, this material achieves a significantly higher negative charge density, enabling high-affinity binding and enhanced interaction capabilities in biochemical and analytical applications.
Manufactured by Michigan Diagnostics LLC, this product is produced with tight control over substitution levels to ensure consistent performance and reproducibility.
Structural and Functional Characteristics
The alpha-cyclodextrin backbone provides a compact cavity suitable for small molecules. When heavily sulfated (DS 8–11), the molecule transitions toward electrostatic interaction dominance, while still retaining some inclusion capability.
The increased charge density enhances binding to positively charged molecules, making it highly effective in systems where charge-based interaction is critical.
Key Properties
- Degree of Substitution: 8–11
- Charge Profile: Strongly anionic
- Water Solubility: Very high
- Cavity Size: ~4.7–5.3 Å
- Functional Mode: Electrostatic dominant
Applications in Protein Binding and Biochemical Systems
High-sulfate alpha cyclodextrin is widely used in systems requiring strong interaction with positively charged proteins or molecules.
Applications include:
- High-affinity protein binding studies
- Charge-based inhibition experiments
- Stabilization of proteins in solution
- Investigation of protein interactions
- Biomolecular research
Analytical and Separation Applications
- Charge-based separation techniques
- Analytical chemistry applications
- Interaction-based chromatography systems
- Molecular recognition studies
Drug Delivery and Formulation
- Interaction with cationic drugs
- Stabilization of small molecule formulations
- Controlled release systems
Why Choose Michigan Diagnostics
- Consistent DS range (8–11)
- High purity and COA
- Fast US shipping
- Custom synthesis available
Order Alpha Cyclodextrin Sulfated (High DS 8–11)
Michigan Diagnostics provides a reliable source of alpha cyclodextrin sulfated high (DS 8–11) for advanced research applications.
Specifications
| Property | Details |
|---|---|
| Form | White to off-white powder |
| Degree of Substitution | 8–11 sulfate groups |
| Cavity Size | Small (alpha, ~4.7–5.3 Å internal diameter) |
| Solubility | Freely soluble in water |
| Storage | Store at room temperature, away from moisture |
| Purity | ≥ 95% |
For research use. Custom quantities and bulk orders available — contact us for pricing.
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