Description
Alpha Cyclodextrin Phosphated Low (DS 3–6)
Alpha-cyclodextrin, phosphated (low degree of substitution 3–6), is a specialized cyclodextrin derivative designed to enhance aqueous solubility and compatibility while maintaining the unique small-cavity structure of native alpha-cyclodextrin. By introducing a controlled number of phosphate groups onto the hydroxyl positions of the cyclodextrin molecule, this material achieves improved hydrophilicity and dispersion without significantly altering its inclusion behavior.
At Michigan Diagnostics LLC, we manufacture high-purity alpha cyclodextrin phosphated (DS 3–6) with strict control over substitution levels. Each batch is produced to ensure consistent quality, reproducibility, and performance across pharmaceutical, biochemical, and analytical applications.
Structural and Functional Characteristics
Alpha-cyclodextrin consists of six α-1,4-linked glucose units arranged in a toroidal structure, forming the smallest internal cavity among the native cyclodextrins. This cavity measures approximately 4.7–5.3 Å in diameter and is particularly well suited for encapsulating small hydrophobic molecules, simple organic compounds, and certain functional groups.
When phosphated at a low degree of substitution (DS 3–6), the molecule becomes more hydrophilic and exhibits improved solubility in aqueous and buffered systems. Unlike highly charged derivatives such as sulfated cyclodextrins, phosphated alpha cyclodextrin provides a milder anionic profile. This allows it to interact with biological systems in a controlled manner without introducing strong electrostatic effects that could disrupt proteins or enzymes.
The result is a material that retains its inclusion complex capabilities while offering enhanced performance in water-based environments.
Key Properties
- Degree of Substitution (DS): 3–6 phosphate groups per molecule
- Charge Profile: Mildly anionic
- Cavity Size: ~4.7–5.3 Å
- Water Solubility: High
- Functional Mode: Inclusion complex + aqueous compatibility
- Buffer Compatibility: Excellent
These characteristics make low-phosphated alpha cyclodextrin particularly useful in systems requiring precise control and stability.
Pharmaceutical and Drug Delivery Applications
Alpha-cyclodextrin phosphated (low DS) is used in pharmaceutical research where small molecules require solubility enhancement and stabilization in aqueous environments. Its small cavity size allows selective encapsulation, making it especially useful for compounds that do not fit efficiently into larger cyclodextrins.
Applications include:
- Solubilization of small hydrophobic APIs
- Stabilization of volatile or labile compounds
- Improved formulation in aqueous systems
- Controlled release of small-molecule therapeutics
- Reduction of degradation in sensitive compounds
The presence of phosphate groups enhances compatibility with physiological conditions, making it suitable for early-stage formulation and development.
Biochemical and Enzyme Applications
One of the key strengths of alpha-cyclodextrin phosphated (low DS) is its compatibility with enzyme systems and delicate biochemical environments. The mild charge profile allows interaction without disrupting protein structure or activity.
Applications include:
- Enzyme stabilization in buffered systems
- Protein-compatible formulation environments
- Reduction of nonspecific binding
- Enhancement of reagent solubility
- Optimization of biochemical assays
Because it avoids strong electrostatic interactions, it is particularly useful in systems requiring gentle and controlled behavior.
Diagnostic and Analytical Applications
Alpha-cyclodextrin phosphated is well suited for use in diagnostic and analytical systems where reagent stability and reproducibility are essential.
Applications include:
- ELISA and enzyme-based assays
- Chemiluminescent assay support
- Analytical separation and chromatography systems
- Reagent stabilization in diagnostic workflows
- Laboratory assay development
Its high compatibility with aqueous buffers ensures reliable performance across a wide range of laboratory conditions.
Performance Advantages in Controlled Systems
Alpha-cyclodextrin phosphated (low DS 3–6) provides a unique advantage in systems where precise control over molecular interactions is required. The combination of a small cavity and moderate hydrophilicity allows researchers to fine-tune interactions without introducing excessive ionic strength.
Additionally, the lower degree of substitution minimizes the risk of nonspecific binding, enabling more accurate interpretation of experimental results. This makes the material particularly valuable in:
- Early-stage drug development
- Small molecule screening
- Enzyme kinetics studies
- Analytical method development
Its predictable behavior ensures consistency across experiments and formulations.
Why Choose Michigan Diagnostics
Choosing a reliable alpha cyclodextrin phosphated supplier in the USA is essential for ensuring quality and consistency.
Michigan Diagnostics offers:
- Tight DS control (3–6) for reproducible performance
- High-purity material with full COA documentation
- US-based manufacturing with fast 2–3 day shipping
- Custom synthesis and bulk supply options
- Technical support for formulation and research
Packaging and Availability
Alpha-cyclodextrin phosphated (low DS 3–6) is available in:
- Research quantities
- Pilot-scale batches
- Bulk commercial volumes
Custom packaging and documentation are available upon request.
Order Alpha Cyclodextrin Phosphated (Low DS 3–6)
If you are looking to buy alpha cyclodextrin phosphated low (DS 3–6), Michigan Diagnostics provides a dependable, high-quality solution with fast delivery and expert support. Contact us today to request pricing or discuss your application needs.
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