Leading Manufacturer of Diagnostic Reagents & Research Biochemicals Since 1998
Michigan Diagnostics LLC specializes in high-performance chemiluminescent substrates, pharmaceutical-grade cyclodextrins, and custom antibody production for researchers and clinical laboratories worldwide.
About Michigan Diagnostics LLC
Founded in 1998 by Dr. Brij P. Giri, Michigan Diagnostics has established itself as a trusted manufacturer of diagnostic reagents, chemiluminescent detection systems, and specialized research biochemicals. Located in Royal Oak, Michigan, our state-of-the-art facility produces high-quality reagents used by academic research institutions, clinical diagnostic laboratories, pharmaceutical companies, and biotechnology firms across six continents.
With over 26 years of experience in biochemical manufacturing, we maintain an unwavering commitment to product quality, scientific innovation, and customer service. Our products support breakthrough research in molecular biology, immunology, drug discovery, and clinical diagnostics.
Our Mission & Vision
Our Mission
To provide scientists, researchers, and healthcare professionals worldwide with reliable, high-performance diagnostic reagents and research biochemicals that advance scientific discovery and improve patient care.
Our Vision
To be the preferred global supplier of innovative biochemical reagents through continuous product development, exceptional quality standards, and responsive customer support.
Core Product Lines & Expertise
Michigan Diagnostics manufactures a comprehensive portfolio of research reagents and diagnostic products:
1. Chemiluminescent Substrates for Western Blotting & ELISA
Our flagship FemtoGlow and AttoGlow product lines represent the gold standard in chemiluminescent Western blot detection. These HRP substrates and alkaline phosphatase substrates deliver exceptional sensitivity, enabling detection of protein targets at femtogram to attogram levels.
FemtoGlow HRP Substrates
- High Sensitivity: Femtogram-level protein detection for Western blotting and immunoassays
- Extended Signal: Stable chemiluminescent signal lasting 30 minutes to 2 hours
- Multiple Formats: Single-bottle and two-bottle formulations for different applications
- ELISA Compatible: Optimized substrates for high-throughput enzyme-linked immunosorbent assays
- Applications: Western blotting, ELISA, dot blot, Southern blot, Northern blot
AttoGlow AP Substrates with Enhancer
- Ultra-High Sensitivity: Attogram-level detection with proprietary enhancer technology
- Extended Plateau: Signal remains stable for 2+ hours after development
- Dual Wavelengths: Available in 450nm and 540nm emission for multiplexing
- Low Background: Optimized formulations minimize non-specific signal
- Ideal For: Rare protein detection, phosphoprotein analysis, membrane reprobing
2. Pharmaceutical-Grade Cyclodextrins
Our cyclodextrin product line serves the pharmaceutical, biotechnology, and food industries with high-purity alpha-cyclodextrin, beta-cyclodextrin, and gamma-cyclodextrin in both native and chemically modified forms.
Cyclodextrin Applications
- Drug Delivery: Solubility enhancement and bioavailability improvement for poorly water-soluble drugs
- Pharmaceutical Formulation: Stabilization of active pharmaceutical ingredients (APIs)
- Taste Masking: Encapsulation of bitter drug compounds
- Chiral Separation: Resolution of enantiomers in analytical chemistry
- Research Applications: Molecular inclusion studies, supramolecular chemistry
Modified Cyclodextrins
We offer sulfated and phosphated cyclodextrin derivatives with controlled degrees of substitution for specialized pharmaceutical research applications.
3. Fluorescent Compounds & Labels
High-purity fluorescent dyes and reactive labels for protein conjugation, nucleic acid labeling, and cellular imaging:
- FAM Series: 5-FAM, 6-FAM, and derivatives for flow cytometry and fluorescence in situ hybridization (FISH)
- ROX/Rhodamine Series: Bright red fluorophores for PCR and multicolor flow cytometry
- FITC Series: Classic fluorescein isothiocyanate reagents for antibody and protein labeling
- NHS Esters: Amine-reactive forms for straightforward bioconjugation
4. Antibodies & Immunoreagents
Polyclonal antibodies and affinity-purified antibodies against small molecules, hormones, and steroids for immunoassay development:
- Anti-T4, Anti-T3, Anti-Cortisol antibodies for hormone immunoassays
- Anti-hCG antibodies for pregnancy testing applications
- Secondary antibodies (anti-rabbit IgG, anti-goat IgG) for Western blotting
- Custom antibody production in rabbit, goat, and sheep hosts
5. Protein Conjugates
Hapten-protein conjugates for antibody production and ELISA development:
- BSA Conjugates: For immunogen preparation and antibody generation
- KLH Conjugates: For maximizing immune response in antibody production
- Enzyme Conjugates: HRP and alkaline phosphatase conjugates for immunoassays
- Biotin Conjugates: For avidin-biotin detection systems
6. Custom Synthesis Services
Comprehensive custom synthesis capabilities including:
- Custom Conjugation: Hapten-protein coupling with controlled ratios
- Antibody Production: Polyclonal antibody generation with full characterization
- Peptide Synthesis: Custom peptides up to 50 amino acids with >95% purity
- Cyclodextrin Modification: Custom chemical modifications to client specifications
- Fluorescent Labeling: Protein and antibody labeling services
Learn more about our custom synthesis services →
Quality Assurance & Regulatory Compliance
Quality is the cornerstone of everything we manufacture. All Michigan Diagnostics products are produced under ISO-compliant quality management systems with rigorous in-process controls and final product testing.
Regulatory Approvals
FDA Approved
Many products carry FDA approval for clinical diagnostic use in the United States
CE Marked
European Union compliance for in vitro diagnostic medical devices
ISO Compliant
Manufacturing processes follow ISO 13485 quality standards
Quality Documentation
Every product batch includes comprehensive documentation:
- Certificate of Analysis (COA): Batch-specific analytical test results
- Safety Data Sheets (SDS): GHS-compliant safety information
- Product Datasheets: Detailed specifications and application guidelines
- Regulatory Certificates: FDA, CE, and other certifications upon request
Read more about our quality standards →
Who We Serve
Michigan Diagnostics serves a diverse global customer base across multiple sectors:
🎓 Academic Research
Universities and research institutions conducting basic and translational research in molecular biology, immunology, biochemistry, and related fields.
🏥 Clinical Laboratories
Hospital laboratories and independent diagnostic labs performing immunoassays, hormone testing, and clinical diagnostics.
💊 Pharmaceutical Companies
Drug development companies requiring cyclodextrins for formulation, antibodies for assay development, and research reagents for drug discovery.
🧬 Biotechnology Firms
Biotech companies developing diagnostics, therapeutics, and research tools requiring high-quality biochemical reagents.
🔬 Contract Research Organizations
CROs conducting preclinical studies, bioanalytical testing, and contract research services for pharmaceutical and biotech clients.
🌍 International Distributors
Regional distributors serving markets in Europe, Asia, Latin America, and other international territories.
Global Reach & International Shipping
With over two decades of experience in international shipping, Michigan Diagnostics supplies diagnostic reagents and research biochemicals to customers in more than 50 countries across six continents.
International Capabilities
- Worldwide Shipping: Fast, reliable delivery to virtually any destination
- Export Documentation: Full compliance with international shipping regulations
- Cold Chain Management: Temperature-controlled shipping for sensitive products
- Customs Support: Assistance with import documentation and customs clearance
- Regional Distributors: Authorized distributors in key international markets
- Multi-Currency Support: Flexible payment options for international customers
Why Choose Michigan Diagnostics?
Our Competitive Advantages
✓ 26+ Years of Expertise
Proven track record in biochemical manufacturing since 1998
✓ Superior Quality
ISO-compliant manufacturing with comprehensive QC testing
✓ Competitive Pricing
Direct manufacturer pricing without distributor markups
✓ Technical Support
PhD-level scientists available for application guidance
✓ Custom Services
Tailored synthesis and conjugation services available
✓ Fast Turnaround
Quick order processing and prompt worldwide shipping
Commitment to Scientific Advancement
At Michigan Diagnostics, we understand that our products contribute to important research that advances human health and scientific knowledge. We take this responsibility seriously and continually invest in:
- Product Innovation: Development of new reagents with improved sensitivity and performance
- Quality Enhancement: Continuous improvement of manufacturing processes and quality systems
- Customer Support: Providing technical expertise to help researchers achieve optimal results
- Regulatory Compliance: Maintaining certifications and meeting evolving regulatory requirements
- Sustainable Practices: Environmental responsibility in chemical manufacturing and waste management
Contact Michigan Diagnostics
Ready to discuss your reagent needs? Our team is here to help.
📍 Address
Michigan Diagnostics LLC
26111 Parmenter Blvd
Royal Oak, MI 48073
United States
📞 Contact
Phone: (248) 435-4472
Fax: (248) 435-4537
Email: [email protected]
🕒 Business Hours
Monday – Friday
9:00 AM – 5:00 PM EST
(Closed weekends and holidays)